Most smokers know cigarettes can damage their lungs, but all too often, they have no idea that smoking is also bad for their blood vessels.

For too many smokers, the first they learn of the connection is when a vascular surgeon diagnoses them with peripheral artery disease (PAD). The disease starts mildly with either no symptoms at all, or with leg pains when walking. If the patient continues poor lifestyle habits, like smoking, PAD slowly starves the toes, feet and legs (peripheral parts of the body) of oxygen, which can lead to gangrene and amputation if not treated.

"Getting our patients to quit smoking is probably the most important thing we can do, probably even more than any surgery we would talk about," said Dr. Matthew Edwards, a vascular surgeon with Wake Forest University School of Medicine. The majority of his vascular patients will think about quitting when faced with their vascular disease, he said, but at least a third have no interest.

"They either refuse to believe what we tell them, or they say, 'I like it too much and what happens happens,'" he said. "We are pretty aggressive in helping them with lots of handholding, counseling and prescriptions, and yet our success rate is 20 to 25%. That's considered a pretty good quit rate, but it's also sad."

Patients with early stage PAD have treatment options other than surgery. But when the disease progresses, smokers may have fewer solutions.

Recent research has shown that smokers have far more surgical complications, and many surgeons are reluctant to operate on them unless it's an emergency. Smoking cessation before surgery is recommended by the Society for Vascular Surgery and the American College of Cardiology among others.

While PAD can affect anyone, a recent study found that of 1,272 patients with PAD, 90% were current or former smokers.

"That's true in our practice," Dr. Edwards said, "and smokers also are presenting younger than non-​smokers. They're showing up in their 40s to 60s, instead of in their late 70s and 80s."

Cigarette smoke contains numerous chemicals that are harmful, but nicotine has perhaps the most powerful negative effects on arteries throughout the body.

By the way, the effects that cigarette smoke has on the blood vessels of the legs are the same all over the body. Some people may suffer a heart attack or a stroke, and some get the most damage in their legs. But if your body is at risk in one area, it is at risk in all areas.

Here are three ways that cigarette smoke damages blood vessels:

• Nicotine is a stimulant, which speeds up the heart by about 20 beats per minute with every cigarette. It raises blood pressure and is a vasoconstrictor, which means it makes arteries all over the body become smaller. That makes it harder for the heart to pump blood through the constricted arteries and it causes the body to release its stores of fat and cholesterol into the blood.
• Smoking accelerates the hardening and narrowing process in arteries. Stiff, narrowed arteries are common in elderly people, but for smokers that process starts earlier, effectively giving them "old" arteries.
• It increases "bad" cholesterol (low-​density lipoprotein) and decreases the "good" cholesterol (high-​density).

While PAD can be severe and limb-​threatening, the good news is that it is a slow-​moving disease, and many patients can keep the worst effects at bay by changing their lifestyles.

Smoking Cessation Seekers are likely aware of the lung-​related health risks of smoking, but fewer may realize that amputation risk associated with the habit. Nearly 72% of these consumers watch a minimum of three hours of TV every day, according to AudienceSCAN, and last year, 62.3% were driven to action by TV commercials. Additionally, within the last year, this audience has been motivated to action by direct mail ads (59%), ads they either saw on their mobile smartphone apps or received via text (54.4%), email ads (51.9%) and outdoor ads (40.2%). They're also 45% more likely than other adults to find ads on social networks useful to them and are active on platforms such as Facebook (83.7%), YouTube (61.4%), Instagram (39.9%) and Twitter (34%).

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